Myelofibrosis
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Myelofibrosis
A rare but important disease that starts in the bone marrow: Myelofibrosis
Myelofibrosis is a chronic disease that occurs when connective tissue (fibrous tissue) replaces bone marrow.
is a progressive hematologic disease. This condition impairs the production of blood cells; in particular
Myelofibrosis is characterized by symptoms such as anemia, splenomegaly and fatigue.
Myelofibrosis belongs to the group of myeloproliferative disorders (MPN) and in some patients can lead to leukemia.
may also carry the risk of transformation. With early diagnosis and proper follow-up, the course of the disease can be largely controlled.
can be taken under.
Symptoms of Myelofibrosis
Fatigue, quick fatigue
Pale skin (due to anemia)
Abdominal fullness and pressure under the left rib (due to splenomegaly)
Loss of appetite, weight loss
Night sweats
Bone and muscle pain
Frequent infections or bruising
In some patients, it can be detected by routine blood tests without symptoms
Causes and Risk Factors
Gene mutations such as JAK2, CALR, MPL are associated with the disease
It is not genetically inherited, but its incidence increases with age
Myelofibrosis in patients with a previous diagnosis of polycythemia verase or essential thrombocythemia transformation can improve
Diagnosis Process
- Complete blood count (CBC): Low hemoglobin, variable platelet and leukocyte values
- Peripheral smear: Irregular cells, drop-shaped red blood cells can be seen
- Bone marrow biopsy: Essential for definitive diagnosis; the degree of fibrosis is assessed
- Molecular tests: JAK2, CALR and MPL mutations are investigated
- Abdominal ultrasound or CT: Spleen and liver size are assessed
Types of Myelofibrosis
- Primary myelofibrosis: Starts directly with this disease
- Secondary myelofibrosis: Transforms from other myeloproliferative diseases (PV, ET)
Treatment Methods
Treatment of myelofibrosis is individualized, based on disease stage, symptoms and genetic mutations takes shape.
Process Management Suitable for Health Tourism Process Management Suitable for Health Tourism
- - Preliminary evaluation of reports and test results for patients coming from abroad
- - Personalized treatment plan with molecular and genetic analysis
- - Preparation for stem cell transplantation in accordance with international protocols
- - Accommodation, transfer and escort support
- - Long-term planning with remote control and monitoring systems
Myelofibrosis may be rare, but it can be controlled.
You can contact us for a second opinion, treatment planning or information about the transplantation process.